A Novel Treatment of Neuroinflammation against Low Back Pain by Soluble Fullerol Nanoparticles
The results obtained from this study clearly suggest that fullerol treatment suppresses the inflammatory responses of DRG and neurons, as well as cellular apoptosis by decreasing the level of ROS and potentially enhancing anti-oxidative enzyme gene expression. Therefore, fullerol has potential to serve as a novel therapeutic agent for low back pain treatment.
Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells–A potential novel treatment for intervertebral disc degeneration
In conclusion, we believe that this is the first observation that fullerol, a potent antioxidant agent, suppresses IL-1 ß-induced ROS and inflammatory cytokine production, inhibits the adipogenic differentiation of BMSCs in vitro and, therefore, may prevent vertebral fatty marrow deposition and inflammatory responses during disc degeneration.
Pathological features of rat lung following inhalation and intratracheal instillation of C60 fullerene
Polyhydroxylated C60 Fullerene (Fullerenol) Attenuates Neutrophilic Lung Inflammation in Mice
The present study shows that quartz-induced neutrophilic inflammation in the lungs can be attenuated by administration of the water-soluble polyhydroxy fullerene derivative, which may be therapeutically relevant as several difficult-to-treat lung diseases are associated with neutrophilic inflammation.
The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system